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Drug Pop Quiz 101

by Dr. O on January 19, 2010

  • Which of the following antidepressants does not have a withdrawal phenomena?
  • Prozac
  • Zoloft
  • Paxil
  • All of the above have a withdrawal phenomena
  • The correct answer is D.

    All of the above antidepressants are known as SSRIs (Selective Serotonin Reuptake Inhibitors). Each of them has an associated Serotonin Withdrawal Dysphoria/ Syndrome.  It is important to note that although all of them will have these side effects, the actual half-life of the individual drugs determine how soon you may begin to experience problems, after you discontinue the drug.*

    Drug Half-Life Experience of Symptoms

    Prozac (Fluoxetine)                long                               14-21 days

    Zoloft (Sertraline)               moderate                           72 hours

    Paxil (Paroxetine)              short                                    12 hours

    • Always discontinue drugs under physician supervision
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